Fredrickson’s classification of lipoprotein phenotypes

year: 1967

knowledge of lipid disorders was non existent half a century ago

this changed after Fredrickson’s classification of lipoprotein phenotypes

this magnum opus was aimed to provide physicians with the information needed to manage dyslipidaemia

fredrickson and colleagues introduced the idea of classifying the various disorders in terms of lipoproteins rather than lipids.

lipoproteins can be separated according to their density on ultracentrifugation into:

• very low density lipoprotein
• low density lipoprotein
• high density lipprotein

or by their electrophoretic mobility into beta and alpha lipoproteins