year: 1975
miller and miller
HDL levels tend to be lower in situations associated with an increased risk of CHD
Millers published a small study that showed HDL cholesterol levels were signficiantly lower in eight normocholesterolaemic patients with CHD than in 14 controls with similar levels of VLDL and LDL cholesterol.
they demonstrated an inverse correlation between HDL cholesterol concentration and the mass of cholesterol present in both the rapidly and slowly exchangeable pools of tissue cholesterol. Since the latter included arterial wall cohlesterol, they proposed that having a low HDL cholesterol level promotes the development of atherosclerosis by impairing the clearance of cholestero lfrom the arterial wall
Miller and MIller showed that in Tangier disease, there is an accumulation of cholesterol in the tissue.
HDL cholesterol is the preferred substrate of Lecithin cholesterol acyltransferase with cholesterol ester transfer protein is involved in the movement of cholesterol from plasma to the liver (reverse cholesterol transport).
They concluded that raising HDL cholesterol would have a favourable effect on atherosclerosis which is limited with the use of fibrates